Meningitis due to intravenous immunoglobulin therapy

In this study, we describe the clinical and laboratory characteristics of IVIG-induced aseptic meningitis in 4 patients with KD. Fundus examination was normal and there was no focal neurological deficit. Establishing a causal relationship between the use of a drug and the onset of symptoms is the hallmark of diagnosis and it is supported by both negative tests for infectious causes and quick resolution of symptoms after drug discontinuation [ 2 ].

Pediatr Asthma Allergy Immunol.

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Table 2 shows the clinical course of the patients. Aseptic meningitis associated with high dose immunoglobulin: Case report. Two patients were treated with intravenous methylprednisolone; the other 2 children were observed carefully without any special therapy.

Meningitis due to intravenous immunoglobulin therapy

Patients appear to be at highest risk after the first administration, especially if receiving rapid, high-dose infusion of IVIG [ 1 , 7 ]. The cotrimoxazole prophylaxis for pneumocystis was continued. Intravenous immunoglobulin: Adverse effects and safe administration. All patients recovered without neurological complications. Unlike infectious meningitis, it is self-limited and treatment is supportive. On the fourth day, after receiving 72 g of IVIG infusion, the patient developed progressively worsening headache, neck pain and recurrent episodes of vomiting. Two patients were treated with intravenous methylprednisolone; the other 2 children were observed carefully without any special therapy. Electrocardiogram and serum potassium level were normal. References 1. Aseptic meningitis and intravenous immunoglobulin therapy.

In addition, the results of CSF bacterial culture were negative in all patients. Possible inciting factors include the IgG itself, various stabilizing products within each of the preparations, cytokine release triggered by the therapy, or cerebrovascular sensitivity in migraineurs.

how long do ivig side effects last

Patients with a history of migraine are more likely to develop aseptic meningitis while receiving intravenous immunoglobulin therapy, regardless of the type of commercial preparation or the infusion rate.

Though aseptic meningitis has also been reported as a serious complication following IVIG therapy.

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Urinary porphobilinogen was negative. The 3 females complained of headache, and the 1-year-old male was irritable and vomited frequently. A final diagnosis of aseptic meningitis was made by negative bacterial culture results. All microbiological tests were negative. This entity may be more prevalent than one would assume from the low number of reported cases. Table 1 shows the background characteristics of these 4 patients. Unlike infectious meningitis, it is self-limited and treatment is supportive.
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Acute aseptic meningitis due to intravenous immunoglobulin therapy in Guillain