The entire GA lesion must be completely visualized on the macula centered image and must be able to be imaged in its entirety and not contiguous with any areas of peripapillary atrophy. Absence of hyperautofluorescence i.
Symbiotic outcomes for wild plants may differ from domesticated cultivars, leading to differential responses to inoculation. To test the framework and to determine potential positive or negative impacts of commercial inoculants, we evaluated the mycorrhizal response of five wild plants and five crop plant species growing with a commercial AM fungal isolate and a locally sourced conspecific to test the questions:.
Please refer to this study by its ClinicalTrials. Adequate clarity of ocular media, adequate pupillary dilation, and fixation to permit the collection of good quality images as determined by the Investigator.
Presence of any pattern of hyperautofluorescence in the junctional zone of GA. To test the framework, we grew two isolates of Rhizoglomus irregulare commercial versus an isolate locally isolatedwith five crop plants and five wild plants endemic to the region that co-occur with the locally sourced fungus.Introduction Arbuscular mycorrhizal AM fungi are obligate root symbionts that provide a wide spectrum of benefits to their hosts, such as improved nutrient uptake and stress tolerance [ 1 ]. Prior participation in another interventional clinical study for geographic atrophy in either eye including investigational oral medication and placebo. This effect may be exacerbated by local adaptation between wild plants and soil biota as native plants respond more positively to local, versus exotic AM fungi [ 36 , 37 ]. Any contraindication to IVT injection including current ocular or periocular infection. Symbiotic outcomes for wild plants may differ from domesticated cultivars, leading to differential responses to inoculation. We designed a theoretical framework to predict how wild plants and crops can respond differently to AM fungal inoculation Fig 1. Criteria Inclusion Criteria: The study eye must meet all inclusion criteria. All plants associating with the commercial fungus had lower leaf P. Benign conditions in the opinion of the investigator such as peripheral retina dystrophy are not exclusionary.
Benign conditions in the opinion of the investigator such as peripheral retina dystrophy are not exclusionary. Presence of an active ocular disease that in the opinion of the Investigator compromises or confounds visual function, including but not limited to, uveitis, other macular diseases e.
Any ocular condition other than GA secondary to AMD that may require surgery or medical intervention during the study period or, in the opinion of the Investigator, could compromise visual function during the study period.